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DrugBank target: P42261

DrugBank target: P42261 (GRIA1_HUMAN)     

Glutamate receptor 1

AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluR-1, GluA1.

Function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 906 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 6 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00753 isoflurane
ICF
Formula: C3H2Clf5O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00142 l-glutamic acid
GGL
Formula: C5H9No4
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB08883 perampanel
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01236 sevoflurane
Formula: C4H3F7O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00228 enflurane
Formula: C3H2Clf5O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01028 methoxyflurane
Formula: C3H4Cl2F2O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01189 desflurane
DSF
Formula: C3H2F6O
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.

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