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DrugBank target: P48728

DrugBank target: P48728 (GCST_HUMAN)     

Example structure of target: 1wsr

( There are 2 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Aminomethyltransferase, mitochondrial

Glycine cleavage system T protein, GCVT.

Function

The glycine cleavage system catalyzes the degradation of glycine..

Enzyme

2.1.2.10   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10- methylenetetrahydrofolate + NH(3).

Disease(s)

Non-ketotic hyperglycinemia (NKH) [MIM:605899]: Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1wsr
1wsv
1wsr
1wsv

Key:    PfamA domain

Sequence length: 402 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 158 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00116 tetrahydrofolic acid
Formula: C19H23N7O6
Structure: There are no structures of this molecule in the PDB.

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