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DrugBank target: P14867

DrugBank target: P14867 (GBRA1_HUMAN)     

Gamma-aminobutyric acid receptor subunit alpha-1

GABA(A) receptor subunit alpha-1.

Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel..

Disease(s)

Epilepsy, childhood absence 4 (ECA4) [MIM:611136]: A subtype of idiopathic generalized epilepsy characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. Tonic-clonic seizures often develop in adolescence. Absence seizures may either remit or persist into adulthood. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Juvenile myoclonic epilepsy 5 (EJM5) [MIM:611136]: A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 456 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 63 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00273 topiramate
TOR
Formula: C12H21No8S
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01107 methyprylon
Formula: C10H17No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00801 halazepam
Formula: C17H12Clf3N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01154 thiamylal
Formula: C12H18N2O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00425 zolpidem
Formula: C19H21N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01437 glutethimide
Formula: C13H15No2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00683 midazolam
08J
Formula: C18H13Clfn3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01028 methoxyflurane
Formula: C3H4Cl2F2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00371 meprobamate
Formula: C9H18N2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00237 butabarbital
Formula: C10H16N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01355 hexobarbital
Formula: C12H16N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01198 zopiclone
Formula: C17H17Cln6O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01351 amobarbital
Formula: C11H18N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01352 aprobarbital
Formula: C10H14N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01559 clotiazepam
Formula: C16H15Cln2Os
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00753 isoflurane
ICF
Formula: C3H2Clf5O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00418 secobarbital
Formula: C12H18N2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00599 thiopental
EDP
Formula: C11H18N2O2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01159 halothane
Formula: C2Hbrclf3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00228 enflurane
Formula: C3H2Clf5O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00189 ethchlorvynol
Formula: C7H9Clo
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01215 estazolam
Formula: C16H11Cln4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01287 dihydroergotoxine
Formula: C34H41N5O8S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01588 prazepam
Formula: C19H17Cln2O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00829 diazepam
DZP
Formula: C16H13Cln2O
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00546 adinazolam
Formula: C19H18Cln5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00306 talbutal
Formula: C11H16N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01205 flumazenil
Formula: C15H14Fn3O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00474 methohexital
Formula: C14H18N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00231 temazepam
Formula: C16H13Cln2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01353 butethal
Formula: C10H16N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01236 sevoflurane
Formula: C4H3F7O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01589 quazepam
Formula: C17H11Clf4N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01567 fludiazepam
Formula: C16H12Clfn2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01068 clonazepam
Formula: C15H10Cln3O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01174 phenobarbital
Formula: C12H12N2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01189 desflurane
DSF
Formula: C3H2F6O
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00898 ethanol
EOH
Formula: C2H6O
Structure: There are 188 PDB structures containing this molecule although none are bound to the above target protein.

 

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Generic name: DB01346 quinidine barbiturate
Formula: C32H36N4O5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01587 ketazolam
Formula: C20H17Cln2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00475 chlordiazepoxide
Formula: C16H14Cln3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00897 triazolam
Formula: C17H12Cl2N4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00292 etomidate
Formula: C14H16N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01354 heptabarbital
Formula: C13H18N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00842 oxazepam
Formula: C15H11Cln2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00837 progabide
Formula: C17H16Clfn2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00543 amoxapine
Formula: C17H16Cln3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00241 butalbital
Formula: C11H16N2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00466 picrotoxin
RI5
Formula: C30H34O13
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00186 lorazepam
Formula: C15H10Cl2N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01594 cinolazepam
Formula: C18H13Clfn3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00628 clorazepate
Formula: C16H11Cln2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00690 flurazepam
FL7
Formula: C21H23Clfn3O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00402 eszopiclone
Formula: C17H17Cln6O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01595 nitrazepam
Formula: C15H11N3O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00794 primidone
Formula: C12H14N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00463 metharbital
Formula: C9H14N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00349 clobazam
Formula: C16H13Cln2O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00404 alprazolam
08H
Formula: C17H13Cln4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00962 zaleplon
Formula: C17H15N5O
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB01381 ginkgo biloba
Formula:
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00312 pentobarbital
RAV
Formula: C11H18N2O3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01558 bromazepam
Formula: C14H10Brn3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00849 methylphenobarbital
Formula: C13H14N2O3
Structure: There are no structures of this molecule in the PDB.

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