spacer
spacer

Search 

DrugBank target: P80404

DrugBank target: P80404 (GABT_HUMAN)     

4-aminobutyrate aminotransferase, mitochondrial

(S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, Gamma-amino-N-butyrate transaminase, L-AIBAT, GABA-AT, GABA transaminase, GABA-T.

Function

Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine..

Enzyme

2.6.1.19   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
2.6.1.22   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2- oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.

Disease(s)

GABA transaminase deficiency (GABATD) [MIM:613163]: An enzymatic deficiency resulting in psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. {ECO:0000269|PubMed:10407778}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 500 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 3 drugs and and 3 nutraceuticals for this target protein:

 

Generic name: DB00160 l-alanine
ALA
Formula: C3H7No2
Structure: There are 1622 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00119 pyruvic acid
PYR
Formula: C3H4O3
Structure: There are 171 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00780 phenelzine
Formula: C8H12N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01080 vigabatrin
Formula: C6H11No2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00142 l-glutamic acid
GGL
Formula: C5H9No4
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00313 valproic acid
2PP
Formula: C8H16O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.

  spacer

spacer