spacer
spacer

Search 

DrugBank target: P14416

DrugBank target: P14416 (DRD2_HUMAN)     

Example structure of target: 1i15

( There are 8 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

D(2) dopamine receptor

Dopamine D2 receptor.

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)..

Disease(s)

Dystonia 11 (DYT11) [MIM:159900]: A myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Note=The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258).

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1i15
2you
1i15
2you
   more ...

Key:    PfamA domain

Sequence length: 442 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 66 drugs for this target protein:

 

 
Generic name: DB00508 triflupromazine
Formula: C18H19F3N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06288 amisulpride
Formula: C17H27N3O4S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00805 minaprine
Formula: C17H22N4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01100 pimozide
Formula: C28H29F2N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01618 molindone
Formula: C16H24N2O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00831 trifluoperazine
TFP
Formula: C21H24F3N3S
Structure: There are 7 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00696 ergotamine
ERM
Formula: C33H35N5O5
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00726 trimipramine
Formula: C20H26N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00734 risperidone
Formula: C23H27Fn4O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06216 asenapine
Formula: C21H20Clno5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00372 thiethylperazine
Formula: C22H29N3S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00875 flupenthixol
Formula: C23H27F3N2Os
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00433 prochlorperazine
P77
Formula: C20H24Cln3S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00915 amantadine
308
Formula: C10H17N
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01425 alizapride
Formula: C16H21N5O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01235 levodopa
DAH
Formula: C9H11No4
Structure: There are 11 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01233 metoclopramide
Formula: C14H22Cln3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00450 droperidol
Formula: C22H22Fn3O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00420 promazine
P2Z
Formula: C17H20N2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB01614 acepromazine
PMZ
Formula: C19H22N2Os
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00334 olanzapine
Formula: C17H20N4S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00543 amoxapine
Formula: C17H16Cln3O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01142 doxepin
D7V
Formula: C19H21No
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01403 methotrimeprazine
Formula: C19H24N2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01184 domperidone
Formula: C22H24Cln5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00623 fluphenazine
Formula: C22H26F3N3Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08815 lurasidone
Formula: C28H36N4O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01392 yohimbine
Formula: C21H26N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04946 iloperidone
Formula: C24H27Fn2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01239 chlorprothixene
Formula: C18H18Clns
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00502 haloperidol
Formula: C21H23Clfno2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01069 promethazine
Formula: C17H20N2S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01200 bromocriptine
08Y
Formula: C32H40Brn5O5
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00248 cabergoline
Formula: C26H37N5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00246 ziprasidone
Formula: C21H21Cln4Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00413 pramipexole
Formula: C10H17N3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00408 loxapine
Formula: C18H18Cln3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00850 perphenazine
Formula: C21H26Cln3Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01038 carphenazine
Formula: C23H29N3O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01238 aripiprazole
Formula: C23H27Cl2N3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01624 zuclopenthixol
Formula: C22H25Cln2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00409 remoxipride
Formula: C16H23Brn2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04842 fluspirilene
Formula: C29H31F2N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01186 pergolide
Formula: C19H26N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00589 lisuride
Formula: C20H26N4O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00477 chlorpromazine
Z80
Formula: C17H19Cln2S
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00714 apomorphine
Formula: C17H17No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00268 ropinirole
Formula: C16H24N2O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00679 thioridazine
LZU
Formula: C21H26N2S2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB06144 sertindole
Formula: C24H26Clfn4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01267 paliperidone
Formula: C23H27Fn4O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01621 pipotiazine
Formula: C24H33N3O3S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01221 ketamine
Formula: C13H16Clno
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00391 sulpiride
Formula: C15H23N3O4S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00490 buspirone
Formula: C21H31N5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00568 cinnarizine
Formula: C26H28N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00363 clozapine
Formula: C18H19Cln4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04844 tetrabenazine
Formula: C19H27No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01224 quetiapine
Formula: C21H25N3O2S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00988 dopamine
LDP
Formula: C8H11No2
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB05271 rotigotine
Formula: C19H25Nos
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00777 propiomazine
Formula: C20H24N2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01622 thioproperazine
Formula: C22H30N4O2S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00933 mesoridazine
Formula: C21H26N2Os2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01623 thiothixene
Formula: C23H29N3O2S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01063 acetophenazine
Formula: C23H29N3O2S
Structure: There are no structures of this molecule in the PDB.

  spacer

spacer