spacer
spacer

Search 

DrugBank target: P08684

DrugBank target: P08684 (CP3A4_HUMAN)     

Example structure of target: 1tqn

( There are 19 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Cytochrome P450 3A4

1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nifedipine oxidase, Quinine 3-monooxygenase, Taurochenodeoxycholate 6-alpha-hydroxylase.

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. {ECO:0000269|PubMed:11159812}..

Enzyme

1.14.13.-   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.14.13.157   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.14.13.32   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.14.13.67   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.14.13.97   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O. {ECO:0000269|PubMed:11159812}.
Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O. {ECO:0000269|PubMed:11159812}.
Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O. {ECO:0000269|PubMed:11159812}.
Albendazole + NADPH + O(2) = albendazole S- oxide + NADP(+) + H(2)O. {ECO:0000269|PubMed:11159812}.
1,8-cineole + NADPH + O(2) = 2-exo-hydroxy- 1,8-cineole + NADP(+) + H(2)O. {ECO:0000269|PubMed:11159812}.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1tqn
1w0e
1w0f
1w0g
   more ...

Key:    PfamA domain

Sequence length: 502 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

 
Generic name: DB01267 paliperidone
Formula: C23H27Fn4O3
Structure: There are no structures of this molecule in the PDB.

  spacer

spacer