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DrugBank target: Q9Y271

DrugBank target: Q9Y271 (CLTR1_HUMAN)     

Cysteinyl leukotriene receptor 1

Cysteinyl leukotriene D4 receptor, G-protein coupled receptor HG55, HMTMF81, CysLTR1, LTD4 receptor.

Function

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 337 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 5 drugs for this target protein:

 

 
Generic name: DB00549 zafirlukast
Formula: C31H33N3O6S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00471 montelukast
MTK
Formula: C35H36Clno3S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00716 nedocromil
Formula: C19H17No7
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01411 pranlukast
Formula: C27H23N5O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00587 cinalukast
Formula: C23H28N2O3S
Structure: There are no structures of this molecule in the PDB.

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