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DrugBank target: P00918

DrugBank target: P00918 (CAH2_HUMAN)     

Example drug-target structure: 1yda

( There are 479 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Carbonic anhydrase 2

Carbonate dehydratase II, Carbonic anhydrase C, Carbonic anhydrase II, CAC, CA-II.

Function

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6..

Enzyme

4.2.1.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

H(2)CO(3) = CO(2) + H(2)O.

Disease(s)

Osteopetrosis, autosomal recessive 3 (OPTB3) [MIM:259730]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

1yda
3caj
2pou
3hku
1cil
1z9y
4m2r

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 259 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 20 drugs for this target protein:

 

Generic name: DB00606 cyclothiazide
CYZ
Formula: C14H16Cln3O4S2
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01031 ethinamate
Formula: C9H13No2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00819 acetazolamide
AZM
Formula: C4H6N4O3S2
Structure: There are 24 PDB structures containing this molecule of which 11 are bound to the above target protein.
Generic name: DB00311 ethoxzolamide
EZL
Formula: C9H10N2O3S2
Structure: There are 4 PDB structures containing this molecule of which 3 are bound to the above target protein.
 
Generic name: DB00436 bendroflumethiazide
Formula: C15H14F3N3O4S2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00774 hydroflumethiazide
HFZ
Formula: C8H8F3N3O4S2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00999 hydrochlorothiazide
HCZ
Formula: C7H8Cln3O4S2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01144 dichlorphenamide
I7A
Formula: C6H6Cl2N2O4S2
Structure: There is one PDB structure containing this molecule and it is bound to the above target protein.
 
Generic name: DB00880 chlorothiazide
Formula: C7H6Cln3O4S2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01119 diazoxide
20J
Formula: C8H7Cln2O2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00273 topiramate
TOR
Formula: C12H21No8S
Structure: There are 2 PDB structures containing this molecule of which 1 is bound to the above target protein.
 
Generic name: DB00232 methyclothiazide
Formula: C9H11Cl2N3O4S2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00909 zonisamide
ZON
Formula: C8H8N2O3S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00869 dorzolamide
ETS
Formula: C10H16N2O4S3
Structure: There are 5 PDB structures containing this molecule of which 4 are bound to the above target protein.
Generic name: DB00695 furosemide
FUN
Formula: C12H11Cln2O5S
Structure: There are 3 PDB structures containing this molecule of which 1 is bound to the above target protein.
 
Generic name: DB01325 quinethazone
Formula: C10H12Cln3O3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01021 trichlormethiazide
Formula: C8H8Cl3N3O4S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00703 methazolamide
Formula: C5H8N4O3S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00562 benzthiazide
Formula: C15H14Cln3O4S3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01194 brinzolamide
BZ1
Formula: C12H21N3O5S3
Structure: There are 3 PDB structures containing this molecule of which 2 are bound to the above target protein.

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