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DrugBank target: P54289

DrugBank target: P54289 (CA2D1_HUMAN)     

Voltage-dependent calcium channel subunit alpha-2/delta-1

Voltage-gated calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2-1, Voltage-dependent calcium channel subunit delta-1.

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity)..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 1103 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 12 drugs for this target protein:

 

 
Generic name: DB01115 nifedipine
Formula: C17H18N2O6
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01054 nitrendipine
Formula: C18H20N2O6
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00270 isradipine
Formula: C19H21N3O5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00381 amlodipine
06X
Formula: C20H25Cln2O5
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00401 nisoldipine
Formula: C20H24N2O6
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06712 nilvadipine
Formula: C19H19N3O6
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04838 cyclandelate
Formula: C17H24O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00308 ibutilide
Formula: C20H36N2O3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00622 nicardipine
Formula: C26H29N3O6
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00996 gabapentin
GBN
Formula: C9H17No2
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00653 magnesium sulfate
Formula: Mgo4S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01023 felodipine
225
Formula: C18H19Cl2No4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.

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