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DrugBank target: P05023

DrugBank target: P05023 (AT1A1_HUMAN)     

Sodium/potassium-transporting ATPase subunit alpha-1

Sodium pump subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit.

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients..

Enzyme

3.6.3.9   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 1023 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 13 drugs for this target protein:

 

 
Generic name: DB01078 deslanoside
Formula: C47H74O19
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01370 aluminium
_AL
Formula: Al
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00511 acetyldigitoxin
Formula: C43H66O14
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00903 ethacrynic acid
EAA
Formula: C13H12Cl2O4
Structure: There are 10 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01119 diazoxide
20J
Formula: C8H7Cln2O2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00774 hydroflumethiazide
HFZ
Formula: C8H8F3N3O4S2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB01092 ouabain
OBN
Formula: C29H44O12
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01021 trichlormethiazide
Formula: C8H8Cl3N3O4S2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00390 digoxin
DGX
Formula: C41H64O14
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01430 almitrine
Formula: C26H29F2N7
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01158 bretylium
Formula: C11H17Brn
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01396 digitoxin
Formula: C41H64O13
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01244 bepridil
BEP
Formula: C24H34N2O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

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