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DrugBank target: P0A6E4

DrugBank target: P0A6E4 (ASSY_ECOLI)     

Example drug-target structure: 1kp2

( There are 4 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Argininosuccinate synthase

Citrulline--aspartate ligase.

Enzyme

6.3.4.5   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule

1kp2

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 446 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

Generic name: DB00536 guanidine
GAI
Formula: Ch5N3
Structure: There are 52 PDB structures containing this molecule of which 2 are bound to the above target protein.

  spacer

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