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DrugBank target: Q12797

DrugBank target: Q12797 (ASPH_HUMAN)     

Example structure of target: 3rcq

( There is one structure corresponding to this UniProt sequence in the PDB. )

Aspartyl/asparaginyl beta-hydroxylase

Aspartate beta-hydroxylase, Peptide-aspartate beta-dioxygenase, ASP beta-hydroxylase.

Function

Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins., Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells..

Enzyme

1.14.11.16   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L-aspartate + succinate + CO(2).

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

3rcq
3rcq

Key:    PfamA domain

Sequence length: 757 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:

 

Generic name: DB00128 l-aspartic acid
IAS
Formula: C4H7No4
Structure: There are 43 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00139 succinic acid
SIN
Formula: C4H6O4
Structure: There are 149 PDB structures containing this molecule although none are bound to the above target protein.

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