DrugBank target: Q12797

DrugBank target: Q12797 (ASPH_HUMAN)     

Example structure of target: 3rcq

( There is one structure corresponding to this UniProt sequence in the PDB. )

Aspartyl/asparaginyl beta-hydroxylase

Aspartate beta-hydroxylase, Peptide-aspartate beta-dioxygenase, ASP beta-hydroxylase.


Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}., Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}..

Enzyme {ECO:0000269|PubMed:11773073}   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L-aspartate + succinate + CO(2). {ECO:0000269|PubMed:11773073}.


Facial dysmorphism, lens dislocation, anterior segment abnormalities, and spontaneous filtering blebs (FDLAB) [MIM:601552]: A syndrome characterized by dislocated crystalline lenses and anterior segment abnormalities in association with a distinctive facies involving flat cheeks and a beaked nose. Some affected individuals develop highly unusual non-traumatic conjunctival cysts (filtering blebs). {ECO:0000269|PubMed:24768550}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.


Key:    PfamA domain

Sequence length: 757 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:


Generic name: DB00128 l-aspartic acid
Formula: C4H7No4
Structure: There are 43 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00139 succinic acid
Formula: C4H6O4
Structure: There are 150 PDB structures containing this molecule although none are bound to the above target protein.