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DrugBank target: Q12797

DrugBank target: Q12797 (ASPH_HUMAN)     

Example structure of target: 3rcq

( There is one structure corresponding to this UniProt sequence in the PDB. )

Aspartyl/asparaginyl beta-hydroxylase

Aspartate beta-hydroxylase, Peptide-aspartate beta-dioxygenase, ASP beta-hydroxylase.

Function

Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. {ECO:0000269|PubMed:11773073}., Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}..

Enzyme

1.14.11.16 {ECO:0000269|PubMed:11773073}   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L-aspartate + succinate + CO(2). {ECO:0000269|PubMed:11773073}.

Disease(s)

Facial dysmorphism, lens dislocation, anterior segment abnormalities, and spontaneous filtering blebs (FDLAB) [MIM:601552]: A syndrome characterized by dislocated crystalline lenses and anterior segment abnormalities in association with a distinctive facies involving flat cheeks and a beaked nose. Some affected individuals develop highly unusual non-traumatic conjunctival cysts (filtering blebs). {ECO:0000269|PubMed:24768550}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

3rcq
3rcq

Key:    PfamA domain

Sequence length: 757 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:

 

Generic name: DB00128 l-aspartic acid
IAS
Formula: C4H7No4
Structure: There are 43 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00139 succinic acid
SIN
Formula: C4H6O4
Structure: There are 150 PDB structures containing this molecule although none are bound to the above target protein.

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