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DrugBank target: P05089

DrugBank target: P05089 (ARGI1_HUMAN)     

Example structure of target: 1wva

( There are 36 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Arginase-1

Liver-type arginase, Type I arginase.

Enzyme

3.5.3.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

L-arginine + H(2)O = L-ornithine + urea.

Disease(s)

Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1wva
1wvb
2aeb
2pha
   more ...

Key:    PfamA domain

Sequence length: 321 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00129 l-ornithine
ORD
Formula: C5H12N2O2
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.

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