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DrugBank target: P29972

DrugBank target: P29972 (AQP1_HUMAN)     

Example structure of target: 1fqy

( There are 4 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Aquaporin-1

Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP-1.

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. {ECO:0000269|PubMed:1373524}..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1fqy
1h6i
1hw0
1ih5

Key:    PfamA domain

Sequence length: 268 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

Generic name: DB00819 acetazolamide
AZM
Formula: C4H6N4O3S2
Structure: There are 25 PDB structures containing this molecule although none are bound to the above target protein.

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