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DrugBank target: P27338

DrugBank target: P27338 (AOFB_HUMAN)     

Example drug-target structure: 3po7

( There are 41 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Amine oxidase [flavin-containing] B

Monoamine oxidase type B, MAO-B.

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine..

Enzyme

1.4.3.4   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

3po7
2xfq

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

Sequence length: 519 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 9 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00909 zonisamide
ZON
Formula: C8H8N2O3S
Structure: There is one PDB structure containing this molecule and it is bound to the above target protein.

 

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Generic name: DB01363 ephedra
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01626 pargyline
Formula: C11H13N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01247 isocarboxazid
Formula: C12H13N3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00780 phenelzine
Formula: C8H12N2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01367 rasagiline
RAS
Formula: C12H13N
Structure: There are 3 PDB structures containing this molecule of which 1 is bound to the above target protein.
Generic name: DB01577 methamphetamine
B40
Formula: C10H15N
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01037 selegiline
Formula: C13H17N
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00752 tranylcypromine
1LP
Formula: C9H11N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00191 phentermine
Formula: C10H15N
Structure: There are no structures of this molecule in the PDB.

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