spacer
spacer

Search 

DrugBank target: P04083

DrugBank target: P04083 (ANXA1_HUMAN)     

Example structure of target: 1ain

( There are 3 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Annexin A1

Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Phospholipase A2 inhibitory protein, p35.

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1ain
1bo9
1qls
1ain

Key:    PfamA domain

Sequence length: 345 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 3 drugs for this target protein:

 

 
Generic name: DB00288 amcinonide
Formula: C28H35Fo7
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01234 dexamethasone
DEX
Formula: C22H29Fo5
Structure: There are 6 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00741 hydrocortisone
HCY
Formula: C21H30O5
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.

  spacer

spacer