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DrugBank target: P01008

DrugBank target: P01008 (ANT3_HUMAN)     

Example structure of target: 1ant

( There are 30 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Antithrombin-III

Serpin C1, ATIII.

Function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin..

Disease(s)

Antithrombin III deficiency (AT3D) [MIM:613118]: An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1ant
1ath
1azx
1br8
   more ...

Key:    PfamA domain  PfamB domain

Sequence length: 463 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 8 drugs for this target protein:

 

 

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Generic name: DB06271 sulodexide
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01109 heparin
Formula:
Structure: There are no structures of this molecule in the PDB.

 

No image

 
Generic name: DB06779 dalteparin
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00407 ardeparin
Formula: C26H42N2O37S5
Structure: There are no structures of this molecule in the PDB.

 

No image

 
Generic name: DB06822 tinzaparin
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00569 fondaparinux sodium
Formula: C31H45N3Na10O49S8
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB08813 nadroparin
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01225 enoxaparin
Formula: C26H42N2O37S5
Structure: There are no structures of this molecule in the PDB.

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