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DrugBank target: P17342

DrugBank target: P17342 (ANPRC_HUMAN)     

Example structure of target: 1jdn

( There are 4 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Atrial natriuretic peptide receptor 3

Atrial natriuretic peptide clearance receptor, Atrial natriuretic peptide receptor type C, ANP-C, ANPR-C, NPR-C.

Function

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1jdn
1jdp
1yk0
1yk1

Key:    PfamA domain  PfamB domain

Sequence length: 540 a.a.

Approved biotech drugs targeting this protein

The DrugBank database identifies 1 biotech drug for this target protein:

 

 

No image

 
Generic name: DB04899 nesiritide
Formula:
Structure: There are no structures of this molecule in the PDB.

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