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DrugBank target: P16066

DrugBank target: P16066 (ANPRA_HUMAN)

Atrial natriuretic peptide receptor 1

Atrial natriuretic peptide receptor type A, Guanylate cyclase A, ANP-A, ANPR-A, NPR-A, GC-A.

Function

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand..

Enzyme

4.6.1.2   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

GTP = 3',5'-cyclic GMP + diphosphate.

Structures

There are currently no structures for this UniProt code in the PDB.

Key:  

Approved drugs / biotech drugs targeting this protein

The DrugBank database identifies 5 drugs and 1 biotech drug for this target protein:

 

 
Generic name: DB00325 nitroprusside
Formula: C5Fen6O
Structure: There are no structures of this molecule in the PDB.

 

No image

 
Generic name: DB04899 nesiritide
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00883 isosorbide dinitrate
Formula: C6H8N2O8
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01612 amyl nitrite
Formula: C5H11No2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00727 nitroglycerin
TNG
Formula: C3H5N3O9
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01613 erythrityl tetranitrate
Formula: C4H6N4O12
Structure: There are no structures of this molecule in the PDB.

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