spacer
spacer

Search 

DrugBank target: Q9BXJ7

DrugBank target: Q9BXJ7 (AMNLS_HUMAN)     

Protein amnionless

Function

Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity)..

Disease(s)

Recessive hereditary megaloblastic anemia 1 (RH-MGA1) [MIM:261100]: Due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 453 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

Generic name: DB00200 hydroxocobalamin
I2A
Formula: C62H89Con13O15P
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

  spacer

spacer