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DrugBank target: Q6NS38

DrugBank target: Q6NS38 (ALKB2_HUMAN)     

Example structure of target: 3btx

( There are 18 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2

Alkylated DNA repair protein alkB homolog 2, DNA oxidative demethylase ALKBH2, Oxy DC1.

Function

Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron..

Enzyme

1.14.11.33   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA- base + formaldehyde + succinate + CO(2).

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

3btx
3bty
3btz
3bu0
   more ...

Key:    PfamA domain

Sequence length: 260 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00126 vitamin c
ASC
Formula: C6H8O6
Structure: There are 23 PDB structures containing this molecule although none are bound to the above target protein.

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