spacer
spacer

Search 

DrugBank target: P05091

DrugBank target: P05091 (ALDH2_HUMAN)     

Example drug-target structure: 1nzw

( There are 27 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Aldehyde dehydrogenase, mitochondrial

ALDH class 2, ALDH-E2, ALDHI.

Enzyme

1.2.1.3   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

1nzw
1o01

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 516 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 2 drugs and and 1 nutraceutical for this target protein:

 

 
Generic name: DB00822 disulfiram
Formula: C10H20N2S4
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 158 PDB structures containing this molecule of which 2 are bound to the above target protein.
Generic name: DB00536 guanidine
GAI
Formula: Ch5N3
Structure: There are 52 PDB structures containing this molecule of which 14 are bound to the above target protein.

  spacer

spacer