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DrugBank target: Q8TD30

DrugBank target: Q8TD30 (ALAT2_HUMAN)     

Example structure of target: 3ihj

( There is one structure corresponding to this UniProt sequence in the PDB. )

Alanine aminotransferase 2

Glutamate pyruvate transaminase 2, Glutamic--alanine transaminase 2, Glutamic--pyruvic transaminase 2, ALT2, GPT 2.

Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate..

Enzyme

2.6.1.2   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

L-alanine + 2-oxoglutarate = pyruvate + L- glutamate.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

3ihj
3ihj
3ihj

Key:    PfamA domain  PfamB domain

Sequence length: 522 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 1 drug and and 2 nutraceuticals for this target protein:

 

 
Generic name: DB00780 phenelzine
Formula: C8H12N2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00142 l-glutamic acid
GGL
Formula: C5H9No4
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00160 l-alanine
ALA
Formula: C3H7No2
Structure: There are 1581 PDB structures containing this molecule although none are bound to the above target protein.

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