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DrugBank target: P24298

DrugBank target: P24298 (ALAT1_HUMAN)     

Alanine aminotransferase 1

Glutamate pyruvate transaminase 1, Glutamic--alanine transaminase 1, Glutamic--pyruvic transaminase 1, ALT1, GPT 1.

Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). {ECO:0000250}..

Enzyme

2.6.1.2   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

L-alanine + 2-oxoglutarate = pyruvate + L- glutamate.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 496 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 1 drug and and 2 nutraceuticals for this target protein:

 

Generic name: DB00142 l-glutamic acid
GGL
Formula: C5H9No4
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00160 l-alanine
ALA
Formula: C3H7No2
Structure: There are 1622 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00780 phenelzine
Formula: C8H12N2
Structure: There are no structures of this molecule in the PDB.

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