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DrugBank target: P49419

DrugBank target: P49419 (AL7A1_HUMAN)     

Example drug-target structure: 2j6l

( There is one structure corresponding to this UniProt sequence in the PDB. )

Alpha-aminoadipic semialdehyde dehydrogenase

Aldehyde dehydrogenase family 7 member A1, Antiquitin-1, Betaine aldehyde dehydrogenase, Delta1-piperideine-6-carboxylate dehydrogenase, Alpha-AASA dehydrogenase, P6c dehydrogenase.

Function

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism..

Enzyme

1.2.1.31   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.2.1.3   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.2.1.8   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

(S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.

Disease(s)

Pyridoxine-dependent epilepsy (PDE) [MIM:266100]: Characterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule

2j6l

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 538 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 158 PDB structures containing this molecule of which 1 is bound to the above target protein.

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