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DrugBank target: P43353

DrugBank target: P43353 (AL3B1_HUMAN)     

Aldehyde dehydrogenase family 3 member B1

Aldehyde dehydrogenase 7.

Function

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation..

Enzyme

1.2.1.5   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 468 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 158 PDB structures containing this molecule although none are bound to the above target protein.

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