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DrugBank target: P30838

DrugBank target: P30838 (AL3A1_HUMAN)     

Example structure of target: 3sza

( There are 5 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Aldehyde dehydrogenase, dimeric NADP-preferring

ALDHIII, Aldehyde dehydrogenase 3, Aldehyde dehydrogenase family 3 member A1.

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes..

Enzyme

1.2.1.5   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

3sza
3szb
4h80
4l1o
   more ...

Key:    PfamA domain

Sequence length: 452 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 166 PDB structures containing this molecule although none are bound to the above target protein.

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