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DrugBank target: P42330

DrugBank target: P42330 (AK1C3_HUMAN)     

Example drug-target structure: 2f38

( There are 31 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Aldo-keto reductase family 1 member C3

17-beta-hydroxysteroid dehydrogenase type 5, 3-alpha-HSD type II, brain, 3-alpha-hydroxysteroid dehydrogenase type 2, Chlordecone reductase homolog HAKRb, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase type I, HA1753, Indanol dehydrogenase, Prostaglandin F synthase, Testosterone 17-beta-dehydrogenase 5, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, 17-beta-HSD 5, 3-alpha-HSD type 2, DD-3, DD3, PGFS.

Function

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone..

Enzyme

1.-.-.-   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.357   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.112   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.188   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.239   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.64   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.3.1.20   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3- oxosteroid + NAD(P)H.
(5Z,13E)-(15S)-9-alpha,11-alpha,15- trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9- alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
Testosterone + NAD(+) = androstenedione + NADH.
Testosterone + NADP(+) = androst-4-ene-3,17- dione + NADPH.
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule

2f38

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 322 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 1 drug and and 1 nutraceutical for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 159 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00905 bimatoprost
15M
Formula: C25H37No4
Structure: There is one PDB structure containing this molecule and it is bound to the above target protein.

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