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DrugBank target: P52895

DrugBank target: P52895 (AK1C2_HUMAN)     

Example drug-target structure: 1ihi

( There are 14 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Aldo-keto reductase family 1 member C2

3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, Dihydrodiol dehydrogenase/bile acid-binding protein, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, DD-2, DD2, DD/BABP.

Function

Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability..

Enzyme

1.-.-.-   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.3.1.20   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.357   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3- oxosteroid + NAD(P)H.

Disease(s)

46,XY sex reversal 8 (SRXY8) [MIM:614279]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure containing drug molecule

1ihi

Key:    PfamA domain  Secondary structure  Bound drug molecule

Sequence length: 322 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 1 drug and and 1 nutraceutical for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 156 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01586 ursodeoxycholic acid
IU5
Formula: C24H40O4
Structure: There are 4 PDB structures containing this molecule of which 1 is bound to the above target protein.

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