spacer
spacer

Search 

DrugBank target: Q04828

DrugBank target: Q04828 (AK1C1_HUMAN)     

Example structure of target: 1mrq

( There are 4 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Aldo-keto reductase family 1 member C1

20-alpha-hydroxysteroid dehydrogenase, Chlordecone reductase homolog HAKRC, Dihydrodiol dehydrogenase 1/2, High-affinity hepatic bile acid-binding protein, Indanol dehydrogenase, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, 20-alpha-HSD, DD1/DD2, HBAB.

Function

Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation..

Enzyme

1.1.1.-   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.149   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.1.1.112   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
1.3.1.20   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha-hydroxyprogesterone + NAD(P)H.
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1mrq
3c3u
3gug
3nty

Key:    PfamA domain

Sequence length: 322 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 2 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 158 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00936 salicyclic acid
SAL
Formula: C7H6O3
Structure: There are 39 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00945 acetylsalicylic acid
AIN
Formula: C9H8O4
Structure: There are 8 PDB structures containing this molecule although none are bound to the above target protein.

  spacer

spacer