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DrugBank target: Q9BYV1

DrugBank target: Q9BYV1 (AGT2_HUMAN)     

Alanine--glyoxylate aminotransferase 2, mitochondrial

(R)-3-amino-2-methylpropionate--pyruvate transaminase, Beta-ALAAT II, Beta-alanine-pyruvate aminotransferase, D-AIBAT, AGT 2.

Function

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure..

Enzyme

2.6.1.44   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
2.6.1.40   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

L-alanine + glyoxylate = pyruvate + glycine.
(R)-3-amino-2-methylpropanoate + pyruvate = 2- methyl-3-oxopropanoate + L-alanine.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 514 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 3 nutraceuticals for this target protein:

 

Generic name: DB00160 l-alanine
ALA
Formula: C3H7No2
Structure: There are 1581 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00119 pyruvic acid
PYR
Formula: C3H4O3
Structure: There are 167 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00145 glycine
GLY
Formula: C2H5No2
Structure: There are 1216 PDB structures containing this molecule although none are bound to the above target protein.

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