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DrugBank target: Q9Y4W6

DrugBank target: Q9Y4W6 (AFG32_HUMAN)     

Example structure of target: 2lna

( There is one structure corresponding to this UniProt sequence in the PDB. )

AFG3-like protein 2

Paraplegin-like protein.

Function

ATP-dependent protease which is essential for axonal development (By similarity)..

Enzyme

3.4.24.-   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Disease(s)

Spinocerebellar ataxia 28 (SCA28) [MIM:610246]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA28 is an autosomal dominant cerebellar ataxia (ADCA) with a slow progressive course and no evidence of sensory involvement or cognitive impairment. Note=The disease is caused by mutations affecting the gene represented in this entry.
Spastic ataxia 5, autosomal recessive (SPAX5) [MIM:614487]: A neurodegenerative disorder characterized by early onset spasticity, peripheral neuropathy, ptosis, oculomotor apraxia, dystonia, cerebellar atrophy, and progressive myoclonic epilepsy. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagram of PDB structure of target.

2lna

Key:    PfamA domain  PfamB domain

Sequence length: 796 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00171 adenosine triphosphate
ATP
Formula: C10H16N5O13P3
Structure: There are 860 PDB structures containing this molecule although none are bound to the above target protein.

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