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DrugBank target: P07327

DrugBank target: P07327 (ADH1A_HUMAN)     

Example structure of target: 1hso

( There are 2 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Alcohol dehydrogenase 1A

Alcohol dehydrogenase subunit alpha.

Enzyme

1.1.1.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1hso
1u3t
1hso
1u3t

Key:    PfamA domain

Sequence length: 374 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 2 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB01213 fomepizole
4PZ
Formula: C4H6N2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00157 nadh
NAI
Formula: C21H29N7O14P2
Structure: There are 158 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00898 ethanol
EOH
Formula: C2H6O
Structure: There are 188 PDB structures containing this molecule although none are bound to the above target protein.

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