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DrugBank target: P18825

DrugBank target: P18825 (ADA2C_HUMAN)     

Alpha-2C adrenergic receptor

Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR.

Function

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 462 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 31 drugs and and 1 nutraceutical for this target protein:

 

 
Generic name: DB00734 risperidone
Formula: C23H27Fn4O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01403 methotrimeprazine
Formula: C19H24N2Os
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00368 norepinephrine
LNR
Formula: C8H11No3
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.

 

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Generic name: DB01363 ephedra
Formula:
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB08815 lurasidone
Formula: C28H36N4O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01392 yohimbine
Formula: C21H26N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00334 olanzapine
Formula: C17H20N4S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00484 brimonidine
Formula: C11H10Brn5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01200 bromocriptine
08Y
Formula: C32H40Brn5O5
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01186 pergolide
Formula: C19H26N2S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00575 clonidine
CLU
Formula: C9H9Cl2N3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00697 tizanidine
Formula: C9H8Cln5S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01577 methamphetamine
B40
Formula: C10H15N
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00248 cabergoline
Formula: C26H37N5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04855 dronedarone
Formula: C31H44N2O5S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04946 iloperidone
Formula: C24H27Fn2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00925 phenoxybenzamine
Formula: C18H22Clno
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06216 asenapine
Formula: C21H20Clno5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00363 clozapine
Formula: C18H19Cln4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00268 ropinirole
Formula: C16H24N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01238 aripiprazole
Formula: C23H27Cl2N3O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01142 doxepin
D7V
Formula: C19H21No
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00413 pramipexole
Formula: C10H17N3S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01267 paliperidone
Formula: C23H27Fn4O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06694 xylometazoline
Formula: C16H24N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00714 apomorphine
Formula: C17H17No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00589 lisuride
Formula: C20H26N4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00246 ziprasidone
Formula: C21H21Cln4Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00800 fenoldopam
Formula: C16H16Clno3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00217 bethanidine
Formula: C10H15N3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06262 droxidopa
Formula: C9H11No5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01224 quetiapine
Formula: C21H25N3O2S
Structure: There are no structures of this molecule in the PDB.

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