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DrugBank target: P35348

DrugBank target: P35348 (ADA1A_HUMAN)     

Alpha-1A adrenergic receptor

Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, Alpha-1A adrenoceptor.

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 466 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 78 drugs for this target protein:

 

Generic name: DB01136 carvedilol
CVD
Formula: C24H26N2O4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01049 ergoloid mesylate
Formula: C30H41N5O8S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01365 mephentermine
Formula: C11H17N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00449 dipivefrin
Formula: C19H29No5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01253 ergonovine
Formula: C19H23N3O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01162 terazosin
TZN
Formula: C19H25N5O4
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB06694 xylometazoline
Formula: C16H24N2
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB06706 isometheptene
Formula: C9H19N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06216 asenapine
Formula: C21H20Clno5
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00668 epinephrine
ALE
Formula: C9H13No3
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB06262 droxidopa
Formula: C9H11No5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00726 trimipramine
Formula: C20H26N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01267 paliperidone
Formula: C23H27Fn4O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01622 thioproperazine
Formula: C22H30N4O2S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00875 flupenthixol
Formula: C23H27F3N2Os
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00696 ergotamine
ERM
Formula: C33H35N5O5
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01200 bromocriptine
08Y
Formula: C32H40Brn5O5
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00346 alfuzosin
Formula: C19H27N5O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04946 iloperidone
Formula: C24H27Fn2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00590 doxazosin
Formula: C23H25N5O5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00734 risperidone
Formula: C23H27Fn4O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00334 olanzapine
Formula: C17H20N4S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB04855 dronedarone
Formula: C31H44N2O5S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00831 trifluoperazine
TFP
Formula: C21H24F3N3S
Structure: There are 7 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB01614 acepromazine
PMZ
Formula: C19H22N2Os
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00622 nicardipine
Formula: C26H29N3O6
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00706 tamsulosin
Formula: C20H28N2O5S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00692 phentolamine
Formula: C17H19N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01224 quetiapine
Formula: C21H25N3O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00964 apraclonidine
Formula: C9H10Cl2N4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01364 ephedrine
Formula: C10H15No
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00368 norepinephrine
LNR
Formula: C8H11No3
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01287 dihydroergotoxine
Formula: C34H41N5O8S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00450 droperidol
Formula: C22H22Fn3O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00679 thioridazine
LZU
Formula: C21H26N2S2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00477 chlorpromazine
Z80
Formula: C17H19Cln2S
Structure: There are 3 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00543 amoxapine
Formula: C17H16Cln3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01069 promethazine
Formula: C17H20N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00797 tolazoline
Formula: C10H12N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00751 epinastine
Formula: C16H15N3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06144 sertindole
Formula: C24H26Clfn4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00363 clozapine
Formula: C18H19Cln4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00925 phenoxybenzamine
Formula: C18H22Clno
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00934 maprotiline
Formula: C20H23N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01295 bevantolol
Formula: C20H27No4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01175 escitalopram
Formula: C20H21Fn2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00610 metaraminol
Formula: C9H13No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00852 pseudoephedrine
Formula: C10H15No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00246 ziprasidone
Formula: C21H21Cln4Os
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00321 amitriptyline
TP0
Formula: C20H23N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB01142 doxepin
D7V
Formula: C19H21No
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.

 

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Generic name: DB06707 levonordefrin
Formula: C9H13No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00298 dapiprazole
Formula: C19H27N5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00935 oxymetazoline
Formula: C16H24N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00215 citalopram
Formula: C20H21Fn2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00388 phenylephrine
Formula: C9H13No2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01579 phendimetrazine
Formula: C12H17No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01403 methotrimeprazine
Formula: C19H24N2Os
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00723 methoxamine
Formula: C11H17No3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01186 pergolide
Formula: C19H26N2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00656 trazodone
Formula: C19H22Cln5O
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00540 nortriptyline
21B
Formula: C19H21N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB01576 dextroamphetamine
1WE
Formula: C9H13N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00420 promazine
P2Z
Formula: C17H20N2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01149 nefazodone
Formula: C25H32Cln5O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01624 zuclopenthixol
Formula: C22H25Cln2Os
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01151 desipramine
DSM
Formula: C18H22N2
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00458 imipramine
IXX
Formula: C19H24N2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00397 phenylpropanolamine
Formula: C9H13No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01238 aripiprazole
Formula: C23H27Cl2N3O2
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00457 prazosin
XRA
Formula: C19H21N5O4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00211 midodrine
Formula: C12H18N2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06711 naphazoline
Formula: C14H14N2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00699 nicergoline
Formula: C24H26Brn3O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00865 benzphetamine
Formula: C17H21N
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00598 labetalol
Formula: C19H24N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06207 silodosin
Formula: C25H32F3N3O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00777 propiomazine
Formula: C20H24N2Os
Structure: There are no structures of this molecule in the PDB.

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