There are 8 structures corresponding
to this UniProt sequence in the PDB. Click the orange, plus icon above
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Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids..
N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate.
Canavan disease (CAND) [MIM:271900]: A rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demyelination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average. Note=The disease is caused by mutations affecting the gene represented in this entry.
Schematic diagram of Pfam domains in target sequence
plus wiring diagrams of PDB structures