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DrugBank target: Q9NR19

DrugBank target: Q9NR19 (ACSA_HUMAN)     

Acetyl-coenzyme A synthetase, cytoplasmic

Acetate--CoA ligase, Acetyl-CoA synthetase, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme, ACS, AceCS.

Function

Activates acetate so that it can be used for lipid synthesis or for energy generation..

Enzyme

6.2.1.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 701 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:

 

Generic name: DB00131 adenosine monophosphate
__A
Formula: C10H14N5O7P
Structure: There are no structures of this molecule in the PDB. However, as a definition of the molecule is given in the PDB's Het Group dictionary, it is possible that there is a structure currently on hold, or that this Het Group is now obsolete.
Generic name: DB00171 adenosine triphosphate
ATP
Formula: C10H16N5O13P3
Structure: There are 844 PDB structures containing this molecule although none are bound to the above target protein.

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