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DrugBank target: Q9NUB1

DrugBank target: Q9NUB1 (ACS2L_HUMAN)     

Acetyl-coenzyme A synthetase 2-like, mitochondrial

Acetate--CoA ligase 2, Acetyl-CoA synthetase 2, Acyl-CoA synthetase short-chain family member 1, AceCS2.

Function

Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)..

Enzyme

6.2.1.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 689 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:

 

Generic name: DB00131 adenosine monophosphate
__A
Formula: C10H14N5O7P
Structure: There are no structures of this molecule in the PDB. However, as a definition of the molecule is given in the PDB's Het Group dictionary, it is possible that there is a structure currently on hold, or that this Het Group is now obsolete.
Generic name: DB00171 adenosine triphosphate
ATP
Formula: C10H16N5O13P3
Structure: There are 862 PDB structures containing this molecule although none are bound to the above target protein.

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