DrugBank target: Q9NUB1

DrugBank target: Q9NUB1 (ACS2L_HUMAN)     

Acetyl-coenzyme A synthetase 2-like, mitochondrial

Acetate--CoA ligase 2, Acetyl-CoA synthetase 2, Acyl-CoA synthetase short-chain family member 1, AceCS2.


Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)..

Enzyme   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.


There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 689 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:


Generic name: DB00131 adenosine monophosphate
Formula: C10H14N5O7P
Structure: There are no structures of this molecule in the PDB. However, as a definition of the molecule is given in the PDB's Het Group dictionary, it is possible that there is a structure currently on hold, or that this Het Group is now obsolete.
Generic name: DB00171 adenosine triphosphate
Formula: C10H16N5O13P3
Structure: There are 862 PDB structures containing this molecule although none are bound to the above target protein.