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DrugBank target: P17787

DrugBank target: P17787 (ACHB2_HUMAN)     

Example structure of target: 2gvt

( There are 5 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Neuronal acetylcholine receptor subunit beta-2

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions..

Disease(s)

Epilepsy, nocturnal frontal lobe, 3 (ENFL3) [MIM:605375]: An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

2gvt
2k58
2k59
2ksr
   more ...

Key:    PfamA domain

Sequence length: 501 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 2 drugs for this target protein:

 

Generic name: DB00674 galantamine
GNT
Formula: C17H21No3
Structure: There are 6 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00184 nicotine
NCT
Formula: C10H14N2
Structure: There are 7 PDB structures containing this molecule although none are bound to the above target protein.

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