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DrugBank target: P43681

DrugBank target: P43681 (ACHA4_HUMAN)     

Example structure of target: 2gvt

( There are 2 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Neuronal acetylcholine receptor subunit alpha-4

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions..

Disease(s)

Epilepsy, nocturnal frontal lobe, 1 (ENFL1) [MIM:600513]: An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

2gvt
2lly
2gvt
2lly

Key:    PfamA domain

Sequence length: 626 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 18 drugs for this target protein:

 

 
Generic name: DB00306 talbutal
Formula: C11H16N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01353 butethal
Formula: C10H16N2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01273 varenicline
QMR
Formula: C13H13N3
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00184 nicotine
NCT
Formula: C10H14N2
Structure: There are 7 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01355 hexobarbital
Formula: C12H16N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01174 phenobarbital
Formula: C12H12N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00849 methylphenobarbital
Formula: C13H14N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00418 secobarbital
Formula: C12H18N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01352 aprobarbital
Formula: C10H14N2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00599 thiopental
EDP
Formula: C11H18N2O2S
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00794 primidone
Formula: C12H14N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00237 butabarbital
Formula: C10H16N2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00312 pentobarbital
RAV
Formula: C11H18N2O3
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB01354 heptabarbital
Formula: C13H18N2O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00674 galantamine
GNT
Formula: C17H21No3
Structure: There are 6 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00463 metharbital
Formula: C9H14N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01351 amobarbital
Formula: C11H18N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00241 butalbital
Formula: C11H16N2O3
Structure: There are no structures of this molecule in the PDB.

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