spacer
spacer

Search 

DrugBank target: Q16515

DrugBank target: Q16515 (ASIC2_HUMAN)     

Acid-sensing ion channel 2

Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive cation channel neuronal 1, Brain sodium channel 1, Mammalian degenerin homolog, ASIC2, BNC1, BNaC1.

Function

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 512 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

Generic name: DB00594 amiloride
AMR
Formula: C6H8Cln7O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

  spacer

spacer