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DrugBank target: O00763

DrugBank target: O00763 (ACACB_HUMAN)     

Example structure of target: 2dn8

( There are 10 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Acetyl-CoA carboxylase 2

ACC-beta, Biotin carboxylase.

Function

ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase..

Enzyme

6.4.1.2   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
6.3.4.14   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

2dn8
2hjw
2kcc
3ff6
   more ...

Key:    PfamA domain  PfamB domain

Sequence length: 2457 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 2 nutraceuticals for this target protein:

 

Generic name: DB00121 biotin
BTN
Formula: C10H16N2O3S
Structure: There are 87 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00173 adenine
ADE
Formula: C5H5N5
Structure: There are 89 PDB structures containing this molecule although none are bound to the above target protein.

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