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DrugBank target: Q13085

DrugBank target: Q13085 (ACACA_HUMAN)     

Example structure of target: 2yl2

( There are 3 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Acetyl-CoA carboxylase 1

ACC-alpha, Biotin carboxylase, ACC1.

Function

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. {ECO:0000269|PubMed:20952656}..

Enzyme

6.4.1.2   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
6.3.4.14   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. {ECO:0000269|PubMed:20952656}.
ATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein]. {ECO:0000269|PubMed:20952656}.

Disease(s)

Acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]: An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth. {ECO:0000269|PubMed:6114432}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

2yl2
3coj
4asi

Key:    PfamA domain  PfamB domain

Sequence length: 2345 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 1 nutraceutical for this target protein:

 

Generic name: DB00121 biotin
BTN
Formula: C10H16N2O3S
Structure: There are 89 PDB structures containing this molecule although none are bound to the above target protein.

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