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DrugBank target: P19801

DrugBank target: P19801 (AOC1_HUMAN)     

Example structure of target: 3hi7

( There are 5 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Amiloride-sensitive amine oxidase [copper-containing]

Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase, DAO, Diamine oxidase, KAO.

Function

Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function..

Enzyme

1.4.3.22   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

Histamine + H(2)O + O(2) = (imidazol-4- yl)acetaldehyde + NH(3) + H(2)O(2).

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

3hi7
3hig
3hii
3k5t
   more ...

Key:    PfamA domain

Sequence length: 750 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 1 drug for this target protein:

 

Generic name: DB00594 amiloride
AMR
Formula: C6H8Cln7O
Structure: There are 2 PDB structures containing this molecule although none are bound to the above target protein.

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