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DrugBank target: O95477

DrugBank target: O95477 (ABCA1_HUMAN)     

ATP-binding cassette sub-family A member 1

ATP-binding cassette transporter 1, Cholesterol efflux regulatory protein, ABC-1, ATP-binding cassette 1.

Function

cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport..

Disease(s)

High density lipoprotein deficiency 1 (HDLD1) [MIM:205400]: Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. Note=The disease is caused by mutations affecting the gene represented in this entry.
High density lipoprotein deficiency 2 (HDLD2) [MIM:604091]: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux. Note=The disease is caused by mutations affecting the gene represented in this entry.

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain  PfamB domain

Sequence length: 2261 a.a.

Approved drugs / nutraceuticals targeting this protein

The DrugBank database identifies 2 drugs and and 1 nutraceutical for this target protein:

 

Generic name: DB00171 adenosine triphosphate
ATP
Formula: C10H16N5O13P3
Structure: There are 860 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB01599 probucol
Formula: C31H48O2S2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01016 glyburide
Formula: C23H28Cln3O5S
Structure: There are no structures of this molecule in the PDB.

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