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DrugBank target: P17174

DrugBank target: P17174 (AATC_HUMAN)     

Example structure of target: 3ii0

( There is one structure corresponding to this UniProt sequence in the PDB. )

Aspartate aminotransferase, cytoplasmic

Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, Glutamate oxaloacetate transaminase 1, Transaminase A, cAspAT, cCAT.

Function

Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain..

Enzyme

2.6.1.1   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  
2.6.1.3   [EC->PDB]   [IntEnz]   [ExPASy]   [KEGG]  

Catalytic activity

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate.

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

3ii0
3ii0
3ii0

Key:    PfamA domain

Sequence length: 412 a.a.

Approved nutraceuticals targeting this protein

The DrugBank database identifies 3 nutraceuticals for this target protein:

 

Generic name: DB00142 l-glutamic acid
GGL
Formula: C5H9No4
Structure: There are 9 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00151 l-cysteine
CYS
Formula: C3H7No2S
Structure: There are 359 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00128 l-aspartic acid
IAS
Formula: C4H7No4
Structure: There are 43 PDB structures containing this molecule although none are bound to the above target protein.

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