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DrugBank target: P29274

DrugBank target: P29274 (AA2AR_HUMAN)     

Example drug-target structure: 3rfm

( There are 20 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Adenosine receptor A2a

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures containing drug molecules

3rfm
2ydo

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

Sequence length: 411 a.a.

Approved drugs / biotech drugs targeting this protein

The DrugBank database identifies 9 drugs and 1 biotech drug for this target protein:

 

Generic name: DB01412 theobromine
37T
Formula: C7H8N4O2
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00277 theophylline
TEP
Formula: C7H8N4O2
Structure: There are 6 PDB structures containing this molecule although none are bound to the above target protein.
 
Generic name: DB00358 mefloquine
Formula: C17H16F6N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06213 regadenoson
Formula: C15H18N8O5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01303 oxtriphylline
Formula: C12H21N5O3
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00201 caffeine
CFF
Formula: C8H10N4O2
Structure: There are 10 PDB structures containing this molecule of which 1 is bound to the above target protein.

 

No image

 
Generic name: DB04932 defibrotide
Formula:
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00806 pentoxifylline
PNX
Formula: C13H18N4O3
Structure: There are 4 PDB structures containing this molecule although none are bound to the above target protein.
Generic name: DB00651 dyphylline
X0T
Formula: C10H14N4O4
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
Generic name: DB00640 adenosine
ADN
Formula: C10H13N5O4
Structure: There are 121 PDB structures containing this molecule of which 1 is bound to the above target protein.

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