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DrugBank target: P01023

DrugBank target: P01023 (A2MG_HUMAN)     

Example structure of target: 1bv8

( There are 5 structures corresponding to this UniProt sequence in the PDB. Click the orange, plus icon above for a list. )

Alpha-2-macroglobulin

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, Alpha-2-M.

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase..

Schematic diagram of Pfam domains in target sequence plus wiring diagrams of PDB structures of target.

1bv8
2p9r
4acq
1bv8
   more ...

Key:    PfamA domain  PfamB domain

Sequence length: 1473 a.a.

Approved drugs / biotech drugs targeting this protein

The DrugBank database identifies 1 drug and 2 biotech drugs for this target protein:

 

 
Generic name: DB00626 bacitracin
Formula: C66H103N17O16S
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB08888 ocriplasmin
Formula: C1214H1890N338O348S14
Structure: There are no structures of this molecule in the PDB.

 

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Generic name: DB00102 becaplermin
Formula: C532H892N162O153S9
Structure: There are no structures of this molecule in the PDB.

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