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DrugBank target: P46098

DrugBank target: P46098 (5HT3A_HUMAN)     

5-hydroxytryptamine receptor 3A

5-hydroxytryptamine receptor 3, Serotonin receptor 3A, Serotonin-gated ion channel receptor, 5-HT3-A, 5-HT3A, 5-HT-3, 5-HT3R.

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:9950429}..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 478 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 18 drugs for this target protein:

 

 
Generic name: DB00721 procaine
Formula: C13H20N2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00377 palonosetron
Formula: C19H24N2O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00246 ziprasidone
Formula: C21H21Cln4Os
Structure: There are no structures of this molecule in the PDB.
Generic name: DB01043 memantine
377
Formula: C12H21N
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00969 alosetron
Formula: C17H18N4O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01238 aripiprazole
Formula: C23H27Cl2N3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00363 clozapine
Formula: C18H19Cln4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00757 dolasetron
Formula: C19H20N2O3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00728 rocuronium
Formula: C32H53N2O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00334 olanzapine
Formula: C17H20N4S
Structure: There are no structures of this molecule in the PDB.
Generic name: DB00889 granisetron
CWB
Formula: C18H24N4O
Structure: There is one PDB structure containing this molecule but it is not bound to the above target protein.
 
Generic name: DB00604 cisapride
Formula: C23H29Clfn3O4
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB06204 tapentadol
Formula: C14H23No
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00370 mirtazapine
Formula: C17H19N3
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00904 ondansetron
Formula: C18H19N3O
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01224 quetiapine
Formula: C21H25N3O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01161 chloroprocaine
Formula: C13H19Cln2O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB01199 tubocurarine
Formula: C37H41N2O6
Structure: There are no structures of this molecule in the PDB.

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