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DrugBank target: P30939

DrugBank target: P30939 (5HT1F_HUMAN)     

5-hydroxytryptamine receptor 1F

Serotonin receptor 1F, 5-HT-1F, 5-HT1F.

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity..

Structures

There are currently no structures for this UniProt code in the PDB.

Schematic diagram of Pfam domains in target sequence

Key:    PfamA domain

Sequence length: 366 a.a.

Approved drugs targeting this protein

The DrugBank database identifies 5 drugs for this target protein:

 

 
Generic name: DB00216 eletriptan
Formula: C22H26N2O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00953 rizatriptan
Formula: C15H19N5
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00315 zolmitriptan
Formula: C16H21N3O2
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00669 sumatriptan
Formula: C14H21N3O2S
Structure: There are no structures of this molecule in the PDB.
 
Generic name: DB00952 naratriptan
Formula: C17H25N3O2S
Structure: There are no structures of this molecule in the PDB.

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